Each uncoated tablet contains:
Praziquantel BP................................ 700 mg
Oxyclozanide BP............................... 700 mg
Excipients............................................... q.s.

Praziquantel is a prazinoisoquinoline derivative anthelmintic, Praziquantel is well absorbed (approximately 80%) from the gastrointestinal tract. However, due to
extensive first-pass metabolism, only a relatively small amount enters systemic circulation. Oxyclozanide is an anthelmintic of the salicylanilide group. Oxyclozanide is slowly absorbed after oral administration with peak plasma levels 24 hours after dosing.

Mechanism of Action:
In cestodes Praziquantel induces ion influx across the tegument of the parasite causing immediate muscular spasm. Low concentrations appear to impair the function of the suckers and to stimulate motility of the worm, while at higher concentrations contraction of the chain of proglottids (the strobila) is increased, this being irreversible at very high concentration of the drug. Disruption of the tegument occurs which makes it more easily attacked by proteolytic enzymes which cause irreversible focal vacuolisation at specific sites of the integument of the cestode. It is effective against Fasciola species, acting as an uncoupler of oxidative phosphorylation. It may act at more than one site to decrease levels of ATP leading to metabolic malfunction and death of the parasite.

•Tapeworms and acute and chronic liver fluke infection in cattle, sheep and goats
•In lambs/calves to treat Moniezia infection
•Effective against T. hydatigena, T. ovis, Moniezia and mature and immature Fasciola spp (F. hepatica and F. gigantic). in cattle, sheep, goats and amphistomiasis in cattle.

Dosage and Administration:
For oral administration.
Cattle : 1 tablet per 70 kg of body weight.
Sheep and Goats: 1 tablet per 50 kg body weight.

Use medicine cautiously in weak and debilitated animals.
Do not administer to animals with known hypersensitivity to the active ingredients.

Adverse Effects:
With Praziquantel the majority of side effects develop due to the release of the contents of the parasites as they are killed and the consequent host immune reaction. Frequently occurring side effects are dizziness, headache, and malaise. Drowsiness, somnolence, fatigue, and vertigo have also been seen. Also abdominal pain or cramps with or without nausea and vomiting observed.

Warnings and Precautions:
No particular precautions are required however in weak and debilitated animals divided doses are recommended. Any change in dose should be done in consultation with the veterinarian.

Withdrawal Period:
Meat: 7 days
Should not be used in Cattle, Sheep and Goats producing milk for human consumption.

Store below 30°C in a dry place, protect from direct sunlight.

Blister packing of 5 x 10 Tablets.