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Composition:
Each ml contains:
Fenbendazole B.P. ......………...100.0 mg
Ivermectin B.P. ……….……...........2.0 mg
Excipients………….……...…….............q.s.


Description:
Fenbendazole belongs to benzimidazole group of anthelmintics compounds. It has a broad spectrum anthelmintic action against a wide range of gastrointestinal nematodes (adult and larval stages) such as roundworms, hookworms, lungworms and tapeworms in livestock animals like cattle, sheep and goat. Fenbendazole acts by binding the subunit of the tubulin of parasitic microtubules. It affects the polymerization process of tubulin resulting in disruption
of energy metabolism of the parasites causing wormicidal effect. The action of benzimidazoles is highly selective on parasites occurring at much lower concentrations than those required for binding mammalian proteins. It has also ovicidal and larvicidal properties. Ivermectin belongs to macrocyclic lactone compounds. It acts against both gastrointestinal nematodes and arthropod parasites. It stimulates the release of gamma amino butyric acid (GABA) at pre-synaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle ber in arthropods. By stimulating the release of GABA, ivermectin causes accid paralysis of the parasite and eventually death.


Indications:
FENACURE-I Suspension is indicated for the removal & control of mature and immature forms of gastrointestinal nematodes such as Roundworms (adult and 4th - stage larvae), Hookworms, Lungworms (adult and larvae) Stomach worms, Tapeworms (heads and segments) and ectoparasites like ticks, mites and sucking lice in cattle, sheep and goats.


Dosage and Administration:
Cattle: Administer at the dose rate of 10 mg of Fenbendazole and 0.2 mg of Ivermectin per kg body weight which is equivalent to 1 ml of Fenacure-I suspension per 10-15 kg body weight orally as a drench.
Sheep & Goat: Administer at the dose rate of 5 mg of Fenbendazole and 0.2 mg of Ivermectin per kg body weight which is equivalent to 1ml of Fenacure-I suspension per 15-20 kg body weight orally as a drench
.


Contra-indications:
Hypersensitive to Fenbendazole or Ivermectin.
SAFETY: Fenbendazole is not reported for any teratogenicity in ruminants and safe to use during pregnancy.
Fenbendazole & Ivermectin


Warning:
Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.
Side Effects:
When used to treat Hypoderma bovis larva in cattle, Ivermectin can induce serious adverse effects by killing the larva when they are in vital organ area. Larva killed in the vertebral canal can cause paralysis and staggering. Larva killed around the gullet can induce salivation and bloat. These effects can be avoided by treating for grubs immediately after the heel y season or after the stages of grub development where these areas would be affected.
Withdrawal Period:
Cattle:
Meat: 35 days,
Milk: Should not be used in cattle producing milk for human consumption or in dairy cows, including pregnant heifers, within 60 days before calving.
Sheep & Goat:
Meat: 15 Days, Milk: 14 days.


Storage:
Store below 30ºC in a dry place.
Presentation:
Bottle of 250 ml, 500 ml, 1000 ml