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Composition:
Each bolus contains:
Fenbendazole BP.......……...3 gm
Ivermectin BP……….…….100 mg
Excipients………….……...........q.s.


Description:
Fenbendazole is a member of benzimidazole group of anthelmintics targeting the subunit of the tubulin of Parasitic Microtubules. It affects the polymerization process of tubulin resulting in disruption of microtubules and causing vermicidal effect. Inhibition of tubulin formation by benzimidazoles disrupts the integrity and transport functions of the cells within parasites and affect the energy metabolism. The action of benzimidazoles is highly selective on parasites
occurring at much lower concentrations then those required for binding mammalian proteins. Ivermectin enhances the release of gamma amino butyric acid (GABA) at pre-synaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle ber in arthropods. By stimulating the release of GABA, Ivermectin causes accid paralysis of the parasite and eventually death. As liver ukes and tapeworms do not use GABA as a peripheral nerve transmitter, Ivermectin is ineffective against these parasites.


Indications:
FENACURE-I is indicated for effective treatment & control of mature and immature gastrointestinal nematodes such as Roundworms (adult and 4th - stage larvae), Hookworms, Lungworms (adult and larvae), Wireworms, Thread neck worms, Stomach worms , Eyeworms , Tapeworms (heads and segments ) and ectoparasites like Mites, Ticks, suckling Lice


Dosage and Administration:
Cattle: 10 mg of Fenbendazole per kg body weight and 0.2 mg of ivermectin per kg body weight or one bolus for 300 kg bodyweight to be administered orally.
Contra-Indications:
Hypersensitive to Fenbendazole or Ivermectin.
Warning:
Fenbendazole does not have any report of teratogenicity and can be administered safely during pregnancy. However, before administering consult a veterinarian.
Side Effects:
When used to treat Hypoderma bovis larva in cattle, Ivermectin can induce serious adverse effects by killing the larva when they are in vital organ area. Larva killed in the vertebral canal can cause paralysis and staggering. Larva killed around the gullet can induce salivation and bloat. These effects can be avoided by treating for grubs immediately after the heel y season or after the stages of grub development where these areas would be affected.


Withdrawal Period:
Cattle:
Meat: 35 days
Milk: Should not be used in cattle producing milk for human consumption or in dairy cows.
Sheep & Goat: Meat: 42 Days, Milk: 14 days.
Pig: Meat: 28 days.

Storage:
Store below 30ºC in a dry place.
Presentation:
50 bolus per pack (5 x 10)