image

Composition:
Each ml contains:
Ivermectin B.P…………..................… 10 mg
Benzyl alcohol B.P……….........….. 1.5% v/v
Propylene glycol B.P. …........…........….. q.s.


Mechanism of Action:
ASHIVER has been shown to cause paralysis by affecting gamma-amino butyric acid (GABA) mediated signals between nerves & muscles in gastrointestinal roundworms and arthropode parasites 


Indications:
ASHIVER is indicated for the treatment and control of internal and external parasites. Gastrointestinal roundworms (adults and fourth stage larvae): Ostertagia spp. including inhibited O, ostertagi, Haemonchus placei, Trichostrongylus axei and Strongyloides papillosus (adults)
Lungworms (adults and fourth stage larvae): Dictyocaulus viviparous and D. filariae.
Eye worms (adults) : Thelazia spp.
Warbles (parasitic stages): Hypoderma bovis and H. lineatum.
Mites: Psoroptes spp., Sarcoptes spp. and Demodex spp.
Ticks: One host ticks like Boophilus microplus
Sucking lice: Linognathus vituli, Haematopinus eurysternus and solenoptes spp.


Contraindication:
ASHIVER should not be used intravenously or intramuscularly. Do not use in lactating cows or in dairy cows during 28 days prior to calving
Dosage and Administration:
Cattle, Buffaloes, Horses, Sheep, Goats, Pigs, Camels and Dogs: Ivermectin injection should be administrated by subcutaneous (SC) route under the
loose skin in front of or behind the shoulder. The recommended dose is 200 mcg ivermectin per kg. body weight or 1ml / 50 kg. body weight. Inject only 10ml per site of injection in large animals. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean and properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary


Warnings:
To be used only subcutaneously Not more than 10 withdrawals
Side Effects:
When used to treat Hypoderma bovis larva in cattle, ivermectin can induce serious adverse effects by killing the larva when they are in vital organ area. Larva killed in the vertebral canal can cause paralysis and staggering. Larva killed around the gullet can induce salivation and bloat. These effects can be avoided by treating for grubs immediately after the Heal fly season or after the stages of grub development where these areas would be affected. Cattle may also experience discomfort or transient swelling at the injection site. Using a maximum of 10 ml at any one-injection site can help minimize these effects
Withdrawal Period :
Meat : Animals must not be slaughtered after last dose for human consumption
Cattle : 21 days
Sheep : 35 days
Pigs : 28 days
Overdosage:
ASHIVER has a high margin of safety and ordinarily overdosing will be of little consequences as
it is safe at doses well in excess of standard / recommended dose
Storage:
Store below 30°C in a dry place, protect from direct sunlight
Presentation:
10 ml, 20 ml, 50 ml, 100 ml, 250 ml and 500 ml vial