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Composition:
Each bolus contains :
Albendazole B.P. .......................................2500 mg
Excipietns.............................................................q.s.


Pharmacological Classification: Anthelmintics used in livestock


Indications:
For removal and control of gastrointstenal roundworms, lungworms, tapeworms and adult liverflukes in cattle & buffaloes.
ASHIALBEN 2500 is a broad spectrum anthelmintic effective in the removal and control of the following internal


Parasites Of Cattle:
Adult Liver Flukes: (Fasciola hepatica)
Heads and Segments of Tapeworms: (Moniezia benedeni, M.expansa)
Adult and 4th Stage Larvae of Intestinal Worms: Thread necked Intestinal Worm (Nematodirus spathiger, N. helvetianus)
Small Intestinal Worm (Cooperia punctata and Concophora)
Adult stage of Intestinal Worms:
Hook Worm (Bunostomum phlebotomum), Bankrupt Worm (Trichostrongylus colubriformis),
Nodular Worm (Oesophagostomum radiatum)
Adult and 4th Stage Larvae of Stomach Worms : Brown Stomach Worms, including 4th stage inhibited larvae(Ostertagia ostertagi) Barberpole Worm (Trichostrongylus axei)
Adult and 4th Stage Larvae of Lung Worms: (Dictyocaulus viviparus)


Contraindications:
Hypersensitive to albendazole or any components of ASHIALBEN 2500
Pharmacodynamics: Albendazole is a benzimidazole anthelmintic active against most nematodes and some cestodes. The drug exerts its anthelmintic activity by interfering with the normal metabolic functioning of the parasite. Albendazole selectively blocks the glucose uptake by adult helminths in the intestine and their tissue dwelling larvae. Inhibition of glucose uptake leads to endogenous depletion of glycogen stored within the parasite. This in turn causes a decrease in the formation of adenosine triphosphate, which is essential to the survival and reproduction of the helminths. By this mechanism, the drug slowly deplets the energy levels of the susceptible parasites, which are initially immobilized and then killed


Dosage:
For the removal of Tape Worms, Thread necked Intestinal Worm, small Intestinal Worm, Hook Worm, Bankrupt Worm, Nodular Worm, give 7.5 mg of Albendazole per kg of body weight or 1 bolus per 300-350 kg bodyweight For the removal of Adult Liver Flukes, give 15 mg of Albendazole per kg of body weight


Side Effects:
Dosage of up to 5 times the therapeutic dose have been given to farm animals without producing significant side effects. Under experimental conditions the toxic effect appears to be associated with anorexia and nausea. The drug is not teratogenic when tested using normal laboratory criteria Albendazole


Precautions:
General: Animals being treated for neurocysticercosis should receive appropriate steroid and anticonvulsant therapy as required. Oral or intravenous corticosteroid should be considered to prevent cerebral hypertensive episodes during the first week of anticysticeral therapy. Cysticerosis may, in rare cases, involve the retina. Before initiating therapy for neurocysticerosis, the animals should be examined for the presence of retinal lesions. If such lesions are visualized, the need for anticysticeral therapy should be weighed against the possibility of retinal damage caused by albendazole induced changes to the retinal lesions.


Warnings:
Cattle must not be slaughtered within 14 days following last treatment and the milk should not be used before 5 days of last treatment


Precaution:
Do not administer to female cattle during first 45 days of pregnancy or for 45 days after removal of bulls. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parastism Interactions:


With other drug :
Albendazole has been shown to induce liver enzymes of the cytochrome P-150 system responsible for its own metabolism. Therefore, there is a theoretical risk of interaction with theophylline, anticonvulsants, anticoagulants, oral contraceptives and oral hypoglycaemics Therefore, care should be exercised during the introduction of albendazole in animals receiving the above groups of compounds Cimetidine and praziquantel have been reported to increase the plasma level of the albendazole active metabolite


Overdosage And Treatment:
No untoward effects were reported. However, symptomatic and general supportive measures are recommended


Storage:
Store below 30°C in a dry place, protect from direct sunlight


Withdrawal Period:
Meat : 10 days
Milk : 3 days
Category Of Distribution:
Veterinary Medicines General Dealer
Shelf Life: 4 years
Presentation:
50 Boli ( Blister Packing of 10 x 5 Boli),
60 Boli and 150 Boli